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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MED1 All Species: 24.85
Human Site: S1252 Identified Species: 49.7
UniProt: Q15648 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15648 NP_004765.2 1581 168478 S1252 S S S G L G S S G S L S Q K T
Chimpanzee Pan troglodytes XP_001172395 1581 168474 S1252 S S S G L G S S G S L S Q K T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537654 1583 168625 S1254 S S S G L G S S G S L S Q K T
Cat Felis silvestris
Mouse Mus musculus Q925J9 1575 167122 S1254 S S S G S A S S G S V S Q K T
Rat Rattus norvegicus NP_001127833 1567 166392 S1238 S S S G S G S S G S L S Q K T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521297 422 46589 N122 K V A H H G E N P A S C P E L
Chicken Gallus gallus XP_418125 1594 169410 S1263 S S S G M G S S G S M S Q K P
Frog Xenopus laevis Q6INP8 1570 165663 S1243 S G L V S S G S L S Q K P N S
Zebra Danio Brachydanio rerio XP_700209 1694 176982 S1310 P I G S G S G S G G N K C S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VP05 1475 149513 S1175 E Y M V K P S S Q E G L K L T
Honey Bee Apis mellifera XP_395879 1811 193227 G1478 S D D Q S S Q G R R D H V Q T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786427 2421 258175 P1698 N S A K L T T P K P G M R A N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 98 N.A. 94.4 93.9 N.A. 24.4 87.6 72.5 56.4 N.A. 22 24.4 N.A. 25.7
Protein Similarity: 100 100 N.A. 98.9 N.A. 97.1 96.5 N.A. 25.7 93.5 81.7 69 N.A. 38.9 41.1 N.A. 38.5
P-Site Identity: 100 100 N.A. 100 N.A. 80 93.3 N.A. 6.6 80 20 13.3 N.A. 20 13.3 N.A. 13.3
P-Site Similarity: 100 100 N.A. 100 N.A. 86.6 93.3 N.A. 33.3 93.3 26.6 20 N.A. 26.6 20 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 0 0 9 0 0 0 9 0 0 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 9 0 0 % C
% Asp: 0 9 9 0 0 0 0 0 0 0 9 0 0 0 0 % D
% Glu: 9 0 0 0 0 0 9 0 0 9 0 0 0 9 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 9 9 50 9 50 17 9 59 9 17 0 0 0 0 % G
% His: 0 0 0 9 9 0 0 0 0 0 0 9 0 0 0 % H
% Ile: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 0 9 9 0 0 0 9 0 0 17 9 50 0 % K
% Leu: 0 0 9 0 34 0 0 0 9 0 34 9 0 9 9 % L
% Met: 0 0 9 0 9 0 0 0 0 0 9 9 0 0 0 % M
% Asn: 9 0 0 0 0 0 0 9 0 0 9 0 0 9 9 % N
% Pro: 9 0 0 0 0 9 0 9 9 9 0 0 17 0 9 % P
% Gln: 0 0 0 9 0 0 9 0 9 0 9 0 50 9 0 % Q
% Arg: 0 0 0 0 0 0 0 0 9 9 0 0 9 0 0 % R
% Ser: 67 59 50 9 34 25 59 75 0 59 9 50 0 9 17 % S
% Thr: 0 0 0 0 0 9 9 0 0 0 0 0 0 0 59 % T
% Val: 0 9 0 17 0 0 0 0 0 0 9 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _